Search for new tools to combat Gram-negative resistant bacteria among amine derivatives of 5-arylidenehydantoin
J Handzlik, E Szymańska, S Alibert, J Chevalier… - Bioorganic & medicinal …, 2013 - Elsevier
A series of amine-alkyl derivatives of 5-arylidenehydantoin 3–21 was evaluated for their
ability to improve antibiotic effectiveness in two strains of Gram-negative Enterobacter
aerogenes: the reference strain (ATCC-13048) and the chloramphenicol-resistant derivative
over-producing the AcrAB-TolC efflux pump (CM-64). Three antibiotics, chloramphenicol,
nalidixic acid and sparfloxacin were used as markers of efflux pump activity. New
compounds (5–16) were obtained within 3–4 step synthesis using Knoevenagel …
ability to improve antibiotic effectiveness in two strains of Gram-negative Enterobacter
aerogenes: the reference strain (ATCC-13048) and the chloramphenicol-resistant derivative
over-producing the AcrAB-TolC efflux pump (CM-64). Three antibiotics, chloramphenicol,
nalidixic acid and sparfloxacin were used as markers of efflux pump activity. New
compounds (5–16) were obtained within 3–4 step synthesis using Knoevenagel …
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